By following this link you will be leaving a Takeda controlled website for a third party website.
Please note that Takeda is not responsible or liable for any third party website and the website may not be appropriate for all audiences.
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Important Safety Information
Do not take Motegrity if you:
are allergic to Motegrity. Allergic reaction symptoms may include trouble breathing, rash, itching and swelling of your face, lips, tongue or throat.
have a tear in your stomach or intestinal wall (bowel perforation), a bowel blockage (intestinal obstruction) or serious conditions of the intestinal wall such as Crohn’s disease, ulcerative colitis.
Before taking Motegrity, tell your healthcare provider (HCP) about all of your medical conditions, including if you:
have or have had depression, suicidal thoughts or actions, or mood problems
have kidney problems. Your HCP may give you a lower dose of Motegrity
are pregnant or plan to become pregnant. It is not known if Motegrity will harm your unborn baby
are breastfeeding or plan to breastfeed. Prucalopride can pass into your breastmilk. Talk with your HCP about the best way to feed your baby if you take Motegrity.
Tell your HCP about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
What are the possible side effects of Motegrity?
Motegrity may cause serious side effects, including:
unusual changes in mood or behavior, thoughts of hurting yourself, trying to hurt yourself, or suicide. Stop taking Motegrity right away and tell your HCP immediately if your depression gets worse, you feel sad, hopeless or begin to have thoughts of suicide, thoughts of hurting yourself or you have tried to hurt yourself or if you develop new depression.
The most common side effects of Motegrity include:
headache
stomach area (abdominal) pain or bloating
nausea
diarrhea
dizziness
vomiting
gas
fatigue
These are not all the possible side effects of Motegrity. Call your doctor for medical advice about side effects.
You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
What is Motegrity?
Motegrity is a prescription medicine used in adults to treat a type of constipation called chronic idiopathic constipation (CIC). Idiopathic means the cause of the constipation is unknown. It is not known if Motegrity is safe and effective in children.
Eligible Commercially Insured patients may pay as little as $15 and receive up to $90 off their co-pay or out of pocket expenses per 30-day supply of Motegrity® (prucalopride). Offer is tiered based on quantity dispensed:
Tier 1: 1-30 tablets; Patient pays $15, up to max $90 benefit for 1 use ($2700 lifetime)
Tier 2: 31-60 tablets; Patient pays $15, up to max $180 benefit for 2 use(s) ($2700 lifetime)
Tier 3: 61-90 tablets; Patient pays $15, up to max $325 benefit for 3 use(s) ($3250 lifetime)
Offer valid for up to 30 uses through offer expiry. A valid Prescriber ID# is required on the prescription. Offer valid for patients ages 18 and older. Offer not valid for cash paying patients.
Restrictions: This offer is valid in the United States, Puerto Rico, and the U.S. Territories. Offer not valid for prescriptions reimbursed under Medicaid, a Medicare drug benefit plan, Tricare, or other federal or state health programs (including any state medical assistance program) or where prohibited by the health insurance provider. Cash Discount Cards and other non-insurance plans are not valid as primary under this offer. If the patient is eligible for drug benefits under any such program, the patient cannot use this offer. By using this offer, the patient certifies that he or she will comply with any terms of his or her health insurance contract requiring notification to his or her payor of the existence and/or value of this offer. Offer not valid for patients under 18 years of age. It is illegal to (or offer to) sell, purchase, or trade this offer. This offer is not transferable and is limited to one offer per person and may not be combined with any other coupon, discount, prescription savings card, rebate, free trial, patient assistance, or other offer. Not valid if reproduced. Void where prohibited by law. Program managed by ConnectiveRx on behalf of Takeda Pharmaceuticals U.S.A., Inc. The parties reserve the right to discontinue, rescind, revoke or amend this offer without notice at any time. This is not health insurance.
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Patient Information
MOTEGRITY® (moe-teh’-gri-tee)
(prucalopride) tablets, for oral use
What is MOTEGRITY?
MOTEGRITY is a prescription medicine used in adults to treat a type of constipation called chronic idiopathic constipation (CIC). Idiopathic means the cause of the constipation is unknown.
It is not known if MOTEGRITY is safe and effective in children.
Do not take MOTEGRITY if you:
are allergic to MOTEGRITY. Allergic reaction symptoms may include trouble breathing, rash, itching and swelling of your face, lips, tongue or throat.
have a tear in your stomach or intestinal wall (bowel perforation), a bowel blockage (intestinal obstruction) or serious conditions of the intestinal wall such as Crohn’s disease or ulcerative colitis.
Before taking MOTEGRITY, tell your healthcare provider about all of your medical conditions, including if you:
have or have had depression, suicidal thoughts or actions, or mood problems.
have kidney problems. Your healthcare provider may give you a lower dose of MOTEGRITY.
are pregnant or plan to become pregnant. It is not known if MOTEGRITY will harm your unborn baby.
Pregnancy Registry: There is a pregnancy registry for women who become pregnant during treatment with MOTEGRITY. The purpose of this registry is to collect information about the health of you and your baby. Talk to your healthcare provider about how you can take part in this registry.
are breastfeeding or plan to breastfeed. Prucalopride can pass into your breastmilk. Talk with your healthcare provider about the best way to feed your baby if you take MOTEGRITY.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
How should I take MOTEGRITY?
Take 1 MOTEGRITY tablet each day or as directed by your healthcare provider.
Take MOTEGRITY exactly as your healthcare provider tells you to take it.
Take MOTEGRITY with or without food.
What are the possible side effects of MOTEGRITY?
MOTEGRITY may cause serious side effects, including:
unusual changes in mood or behavior, thoughts of hurting yourself, trying to hurt yourself, or suicide. Stop taking MOTEGRITY right away and tell your healthcare provider immediately if your depression gets worse, you feel sad, hopeless, begin to have thoughts of suicide, thoughts of hurting yourself or you have tried to hurt yourself or if you develop new depression.
The most common side effects of MOTEGRITY include:
headache
stomach area (abdominal) pain or bloating
nausea
diarrhea
dizziness
vomiting
gas
fatigue
These are not all the possible side effects of MOTEGRITY.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
How should I store MOTEGRITY?
Store MOTEGRITY at room temperature between 68°F to 77°F (20°C to 25°C).
Store MOTEGRITY in the original container to protect from moisture.
Keep MOTEGRITY and all medicines out of the reach of children.
General information about the safe and effective use of MOTEGRITY.
Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use MOTEGRITY for a condition for which it was not prescribed. Do not give MOTEGRITY to other people, even if they have the same symptoms that you have. It may harm them. You can ask your pharmacist or healthcare provider for information about MOTEGRITY that is written for health professionals.
What are the ingredients in MOTEGRITY?
Active ingredient: prucalopride
Inactive ingredients: colloidal silicon dioxide, lactose monohydrate, magnesium stearate and microcrystalline cellulose. The coating contains hypromellose, lactose monohydrate, polyethylene glycol 3000, titanium dioxide and triacetin. The 2 mg tablet also contains red iron oxide, yellow iron oxide and FD&C Blue #2.
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Actor Portrayal
The Basics of Chronic Idiopathic Constipation
Interested in learning more about Chronic Idiopathic Constipation (CIC)? You've come to the right place!
Chronic Idiopathic Constipation (CIC) is a condition that affects bowel function, where “chronic” means having symptoms for at least 6 months, while “idiopathic” means that the specific cause isn’t known. Patients with CIC in the Motegrity clinical studies may have experienced the following symptoms:
Infrequent and/or incomplete bowel movements
Straining at defecation
Hard stools
Did you know?
Even though CIC and other GI diseases are different, some of the symptoms may be similar.
If these symptoms sound familiar to you, you're not alone. Speak to your doctor about CIC.
Don't worry... you're not alone!
Talking about CIC can be uncomfortable.
An estimated 17.8 million adults in the US* may be affected by Chronic Idiopathic Constipation
*Based on 258.3 million adults living in the US in 2020 and a US prevalence of 6.9%. Treatment may not be appropriate for everyone who has CIC.
Speak up
Be your own best advocate and voice your concerns to your doctor
Talking about your CIC experience with friends and family may provide support
Talk to your doctor about Chronic Idiopathic Constipation and treatment options that may be right for you
What are the risk factors of CIC?
In other words, is Chronic Idiopathic Constipation more likely to affect some than others? Here are a few of the possible risk factors that may contribute to developing CIC:
Gender
Women are more at-risk than men
Age
The risk of CIC increases as you age
Diet
Low-calorie diets may increase risk
Sedentary Lifestyle
Lack of physical activity and exercise may also increase risk
Low Fiber & Water Intake
Not consuming enough of either may lead to developing CIC
Other Medications
Those taking certain medications may be at an increased risk
Keep in mind
Although there are several risk factors associated with CIC, you may still develop this condition even if these risk factors do not apply to you.
What are some ways to better manage CIC?
Don't let CIC get the best of you. If you're having a hard time dealing with your condition, here are some tips and tricks that may help to better manage your symptoms.
Fiber Intake
Gradually increase the amount of fiber you consume to 20 to 30 g
per day
Water Intake
Ensure you're hydrating enough every day
Exercise
Try to incorporate regular exercise into your daily routine
Stress Levels
Do what you can to reduce the amount of stress in your life
How could my diet impact CIC?
The fiber in the foods you eat may help make your stools easier (or harder) to pass. The following are some tips around diet that may help manage your CIC:
Your doctor may recommend adding fiber to your diet
Foods high in insoluble fiber include whole grains, legumes, fruits, and nuts
Keep in mind
If you’ve already tried making these changes to your lifestyle, and you still aren’t finding the relief you’re looking for, it may be time to speak with your doctor about Motegrity.
Not sure how? Here's a useful tool to help guide you through the discussion.
Please expand for Indication and Important Safety Information.
Do not take Motegrity if you:
are allergic to Motegrity. Allergic reaction symptoms may include trouble breathing, rash, itching and swelling of your face, lips, tongue or throat.
have a tear in your stomach or intestinal wall (bowel perforation), a bowel blockage (intestinal obstruction) or serious conditions of the intestinal wall such as Crohn’s disease, ulcerative colitis.
Before taking Motegrity, tell your healthcare provider (HCP) about all of your medical conditions, including if you:
have or have had depression, suicidal thoughts or actions, or mood problems.
have kidney problems. Your HCP may give you a lower dose of Motegrity.
are pregnant or plan to become pregnant. It is not known if Motegrity will harm your unborn baby.
are breastfeeding or plan to breastfeed. Prucalopride can pass into your breastmilk. Talk with your HCP about the best way to feed your baby if you take Motegrity.
Tell your HCP about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
What are the possible side effects of Motegrity?
Motegrity may cause serious side effects, including:
unusual changes in mood or behavior, thoughts of hurting yourself, trying to hurt yourself, or suicide. Stop taking Motegrity right away and tell your HCP immediately if your depression gets worse, you feel sad, hopeless or begin to have thoughts of suicide, thoughts of hurting yourself or you have tried to hurt yourself or if you develop new depression.
The most common side effects of Motegrity include:
headache
stomach area (abdominal) pain or bloating
nausea
diarrhea
dizziness
vomiting
gas
fatigue
These are not all the possible side effects of Motegrity. Call your doctor for medical advice about side effects.
You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
WHAT IS MOTEGRITY?
Motegrity is a prescription medicine used in adults to treat a type of constipation called chronic idiopathic constipation (CIC). Idiopathic means the cause of the constipation is unknown. It is not known if Motegrity is safe and effective in children.
