By following this link you will be leaving a Takeda controlled website for a third party website.
Please note that Takeda is not responsible or liable for any third party website and the website may not be appropriate for all audiences.
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Important Safety Information
Do not take Motegrity if you:
are allergic to Motegrity. Allergic reaction symptoms may include trouble breathing, rash, itching and swelling of your face, lips, tongue or throat.
have a tear in your stomach or intestinal wall (bowel perforation), a bowel blockage (intestinal obstruction) or serious conditions of the intestinal wall such as Crohn’s disease, ulcerative colitis.
Before taking Motegrity, tell your healthcare provider (HCP) about all of your medical conditions, including if you:
have or have had depression, suicidal thoughts or actions, or mood problems
have kidney problems. Your HCP may give you a lower dose of Motegrity
are pregnant or plan to become pregnant. It is not known if Motegrity will harm your unborn baby
are breastfeeding or plan to breastfeed. Prucalopride can pass into your breastmilk. Talk with your HCP about the best way to feed your baby if you take Motegrity.
Tell your HCP about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
What are the possible side effects of Motegrity?
Motegrity may cause serious side effects, including:
unusual changes in mood or behavior, thoughts of hurting yourself, trying to hurt yourself, or suicide. Stop taking Motegrity right away and tell your HCP immediately if your depression gets worse, you feel sad, hopeless or begin to have thoughts of suicide, thoughts of hurting yourself or you have tried to hurt yourself or if you develop new depression.
The most common side effects of Motegrity include:
headache
stomach area (abdominal) pain or bloating
nausea
diarrhea
dizziness
vomiting
gas
fatigue
These are not all the possible side effects of Motegrity. Call your doctor for medical advice about side effects.
You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
What is Motegrity?
Motegrity is a prescription medicine used in adults to treat a type of constipation called chronic idiopathic constipation (CIC). Idiopathic means the cause of the constipation is unknown. It is not known if Motegrity is safe and effective in children.
Eligible Commercially Insured patients may pay as little as $15 and receive up to $90 off their co-pay or out of pocket expenses per 30-day supply of Motegrity® (prucalopride). Offer is tiered based on quantity dispensed:
Tier 1: 1-30 tablets; Patient pays $15, up to max $90 benefit for 1 use ($2700 lifetime)
Tier 2: 31-60 tablets; Patient pays $15, up to max $180 benefit for 2 use(s) ($2700 lifetime)
Tier 3: 61-90 tablets; Patient pays $15, up to max $325 benefit for 3 use(s) ($3250 lifetime)
Offer valid for up to 30 uses through offer expiry. A valid Prescriber ID# is required on the prescription. Offer valid for patients ages 18 and older. Offer not valid for cash paying patients.
Restrictions: This offer is valid in the United States, Puerto Rico, and the U.S. Territories. Offer not valid for prescriptions reimbursed under Medicaid, a Medicare drug benefit plan, Tricare, or other federal or state health programs (including any state medical assistance program) or where prohibited by the health insurance provider. Cash Discount Cards and other non-insurance plans are not valid as primary under this offer. If the patient is eligible for drug benefits under any such program, the patient cannot use this offer. By using this offer, the patient certifies that he or she will comply with any terms of his or her health insurance contract requiring notification to his or her payor of the existence and/or value of this offer. Offer not valid for patients under 18 years of age. It is illegal to (or offer to) sell, purchase, or trade this offer. This offer is not transferable and is limited to one offer per person and may not be combined with any other coupon, discount, prescription savings card, rebate, free trial, patient assistance, or other offer. Not valid if reproduced. Void where prohibited by law. Program managed by ConnectiveRx on behalf of Takeda Pharmaceuticals U.S.A., Inc. The parties reserve the right to discontinue, rescind, revoke or amend this offer without notice at any time. This is not health insurance.
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Patient Information
MOTEGRITY® (moe-teh’-gri-tee)
(prucalopride) tablets, for oral use
What is MOTEGRITY?
MOTEGRITY is a prescription medicine used in adults to treat a type of constipation called chronic idiopathic constipation (CIC). Idiopathic means the cause of the constipation is unknown.
It is not known if MOTEGRITY is safe and effective in children.
Do not take MOTEGRITY if you:
are allergic to MOTEGRITY. Allergic reaction symptoms may include trouble breathing, rash, itching and swelling of your face, lips, tongue or throat.
have a tear in your stomach or intestinal wall (bowel perforation), a bowel blockage (intestinal obstruction) or serious conditions of the intestinal wall such as Crohn’s disease or ulcerative colitis.
Before taking MOTEGRITY, tell your healthcare provider about all of your medical conditions, including if you:
have or have had depression, suicidal thoughts or actions, or mood problems.
have kidney problems. Your healthcare provider may give you a lower dose of MOTEGRITY.
are pregnant or plan to become pregnant. It is not known if MOTEGRITY will harm your unborn baby.
Pregnancy Registry: There is a pregnancy registry for women who become pregnant during treatment with MOTEGRITY. The purpose of this registry is to collect information about the health of you and your baby. Talk to your healthcare provider about how you can take part in this registry.
are breastfeeding or plan to breastfeed. Prucalopride can pass into your breastmilk. Talk with your healthcare provider about the best way to feed your baby if you take MOTEGRITY.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
How should I take MOTEGRITY?
Take 1 MOTEGRITY tablet each day or as directed by your healthcare provider.
Take MOTEGRITY exactly as your healthcare provider tells you to take it.
Take MOTEGRITY with or without food.
What are the possible side effects of MOTEGRITY?
MOTEGRITY may cause serious side effects, including:
unusual changes in mood or behavior, thoughts of hurting yourself, trying to hurt yourself, or suicide. Stop taking MOTEGRITY right away and tell your healthcare provider immediately if your depression gets worse, you feel sad, hopeless, begin to have thoughts of suicide, thoughts of hurting yourself or you have tried to hurt yourself or if you develop new depression.
The most common side effects of MOTEGRITY include:
headache
stomach area (abdominal) pain or bloating
nausea
diarrhea
dizziness
vomiting
gas
fatigue
These are not all the possible side effects of MOTEGRITY.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
How should I store MOTEGRITY?
Store MOTEGRITY at room temperature between 68°F to 77°F (20°C to 25°C).
Store MOTEGRITY in the original container to protect from moisture.
Keep MOTEGRITY and all medicines out of the reach of children.
General information about the safe and effective use of MOTEGRITY.
Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use MOTEGRITY for a condition for which it was not prescribed. Do not give MOTEGRITY to other people, even if they have the same symptoms that you have. It may harm them. You can ask your pharmacist or healthcare provider for information about MOTEGRITY that is written for health professionals.
What are the ingredients in MOTEGRITY?
Active ingredient: prucalopride
Inactive ingredients: colloidal silicon dioxide, lactose monohydrate, magnesium stearate and microcrystalline cellulose. The coating contains hypromellose, lactose monohydrate, polyethylene glycol 3000, titanium dioxide and triacetin. The 2 mg tablet also contains red iron oxide, yellow iron oxide and FD&C Blue #2.
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What to Expect Hero
Actor Portrayal
Moving with Motegrity
From CIC relief to possible side effects and dosing, here's what to expect with Motegrity, an FDA-approved prescription medicine for adults with Chronic Idiopathic Constipation (CIC).
Chronic means having symptoms for at least 6 months.
Idiopathic means the cause of the constipation is unknown.
Chronic means having symptoms for at least 6 months. Idiopathic means the cause of the constipation is unknown.
The ability of Motegrity to relieve the infrequency of bowel movements was studied in six clinical trials of 12-week duration (Studies 1-5) and 24-week duration (Study 6) with 2,484 adults living with Chronic Idiopathic Constipation (CIC). About 3 in 4 were women, with an average age of 47 (ranging from 17 to 95). Many had been living with symptoms of CIC for years. While your results may vary,here's how Motegrity was shown to help:
It's about having ‘complete’ trips more often
If you've lived with CIC, you may know how difficult getting that “complete” feeling can be when it comes to your complete spontaneous bowel movements (BMs). During 12-week studies, Motegrity was shown to help normalize the number of complete spontaneous BMs per week for adults living with CIC (and by normalize, we mean at least 3 complete spontaneous BMs per week on average).
Relief held steady through 12-week studies
Motegrity improved the number of complete spontaneous BMs per week as early as week 1. And what's more? This improvement was maintained through week 12 (which was the length of the studies).
And if you're tired of waiting:
People who started Motegrity had their first complete spontaneous BM from 7 to 15 days sooner, on average, than those taking a placebo — a pill with no active ingredient (ranged from 1.4 to 4.7 days compared with 9.1 to 20.6 days).
Possible Side Effects
The safety profile of Motegrity was studied in six clinical trials involving more than 2,500 adults with CIC, about half of whom received Motegrity. Motegrity may cause serious side effects, including: unusual changes in mood or behavior, thoughts of hurting yourself, trying to hurt yourself, or suicide. Stop taking Motegrity right away and tell your healthcare provider immediately if your depression gets worse, you feel sad, hopeless or begin to have thoughts of suicide, thoughts of hurting yourself or you have tried to hurt yourself or if you develop new depression.
The most common side effects of Motegrity include: headache, stomach area (abdominal) pain or bloating, nausea, diarrhea, dizziness, vomiting, gas and fatigue. If reported, diarrhea or headache typically occurred within the first week of treatment and resolved within a few days of continued use.
These are not all the possible side effects of Motegrity. Call your doctor for medical advice about side effects.
Your doctor can tell you more about Motegrity. Not sure how to ask?
There's no need to complicate things with Motegrity.
Just one tablet a day. Anytime. With or without food. And of course, always follow your doctor's specific instructions — if you have kidney problems, your doctor may give you a lower dose of Motegrity.
Staying on track!
Motegrity was shown to be effective when taken once daily, so it's very important to take it every day as prescribed — not just on days when you are experiencing symptoms.
Store your Motegrity properly
Motegrity should stay in its original container (it protects from moisture)
Store the container at room temperature (68°F to 77°F)
Keep Motegrity and all medicines out of the reach of children
CIC is a bowel condition with symptoms of lumpy or hard stools, straining, and difficult, infrequent or incomplete bowel movements. Women are more likely to get it than men, and the chances of getting it increase with age and lower calorie intake.
To learn more about CIC, including its symptoms and associated risk factors, click here.
Motegrity targets a receptor in your colon involved in natural movements of the colon muscle (known as peristalsis). You can learn more about how Motegrity works by clicking here.
While your results may vary, people who started Motegrity in clinical studies had their first complete spontaneous bowel movement within 1.4 to 4.7 days, compared with 9.1 to 20.6 days for people taking placebo. Learn more about the results and what to expect here.
While everyone's body is different, improvements on weekly complete spontaneous BMs were maintained through the 12-week clinical studies. Learn more about the results and what to expect here.
One tablet of Motegrity should be taken once a day, anytime, with or without food (or exactly as directed by your doctor). It may help to follow a routine like “after breakfast” or “before bed” so you don’t forget. See more dosing information here.
Motegrity may cause serious side effects, including unusual changes in mood or behavior, thoughts of hurting yourself, trying to hurt yourself, or suicide. Stop taking Motegrity right away and tell your healthcare provider immediately if your depression gets worse, you feel sad, hopeless or begin to have thoughts of suicide, thoughts of hurting yourself or you have tried to hurt yourself or if you develop new depression.
Common side effects of Motegrity include headache, stomach area (abdominal) pain or bloating, nausea, diarrhea, dizziness, vomiting, gas and fatigue. These are not all the possible side effects of Motegrity. Call your doctor for medical advice about side effects. Learn more about side effects and what to expect here.
Do not take Motegrity if you are allergic to Motegrity. Allergic reaction symptoms may include trouble breathing, rash, itching and swelling of your face, lips, tongue or throat. You should also not take Motegrity if you have a tear in your stomach or intestinal wall (bowel perforation), a bowel blockage (intestinal obstruction) or serious conditions of the intestinal wall such as Crohn’s disease or ulcerative colitis.
Takeda offers support to patients that need help paying for Motegrity through the Help At Hand program. Click the link to learn more and to find out if you are eligible.
Please expand for Indication and Important Safety Information.
Do not take Motegrity if you:
are allergic to Motegrity. Allergic reaction symptoms may include trouble breathing, rash, itching and swelling of your face, lips, tongue or throat.
have a tear in your stomach or intestinal wall (bowel perforation), a bowel blockage (intestinal obstruction) or serious conditions of the intestinal wall such as Crohn’s disease, ulcerative colitis.
Before taking Motegrity, tell your healthcare provider (HCP) about all of your medical conditions, including if you:
have or have had depression, suicidal thoughts or actions, or mood problems.
have kidney problems. Your HCP may give you a lower dose of Motegrity.
are pregnant or plan to become pregnant. It is not known if Motegrity will harm your unborn baby.
are breastfeeding or plan to breastfeed. Prucalopride can pass into your breastmilk. Talk with your HCP about the best way to feed your baby if you take Motegrity.
Tell your HCP about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
What are the possible side effects of Motegrity?
Motegrity may cause serious side effects, including:
unusual changes in mood or behavior, thoughts of hurting yourself, trying to hurt yourself, or suicide. Stop taking Motegrity right away and tell your HCP immediately if your depression gets worse, you feel sad, hopeless or begin to have thoughts of suicide, thoughts of hurting yourself or you have tried to hurt yourself or if you develop new depression.
The most common side effects of Motegrity include:
headache
stomach area (abdominal) pain or bloating
nausea
diarrhea
dizziness
vomiting
gas
fatigue
These are not all the possible side effects of Motegrity. Call your doctor for medical advice about side effects.
You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
WHAT IS MOTEGRITY?
Motegrity is a prescription medicine used in adults to treat a type of constipation called chronic idiopathic constipation (CIC). Idiopathic means the cause of the constipation is unknown. It is not known if Motegrity is safe and effective in children.
